Neurometric and Psychometric Studies show Improvement in Children with Mental Retardation (MR) due to perinatal Hypoxia after Therapy with Fibroblast Growth Factor (FGF). II Gesell Test
9th World Congress of the International Association for the Scientific Study of Mental Deficiency.
5 – 9 August 1992; Queensland, Australia.
L.C. AGUILAR, P. ROSIQUE*, R. CORTES, A. ISLAS AND J.M. CANTU.
Inst. Invest. Neuroplast. Des. Cel. and Div. Genet. UIBO, I.M.S.S. Guadalajara, México.
Previous studies have shown that FGF stimulates the recovery in mental retardation increasing DQ and IQ (Aguilar et al. Rev. Cub. Invest. Biomed. 10:90, 1991). We present here a new experience using the Gesell scale in 62 patients of both sexes, aged between 1 and 8 years, with exogenous mental retardation. Two groups (G) control (C, n=22) and experimental (E, n=40), were further subdivided by age in A (o-4 years) and B (5-8). Both GEs received FGF (IM, 0.7 ug/kg every 2-4 weeks) during 12 months. Results showed a significant increase (p 0.001) in the rate of development (RD) of GEs, more remarkable at the 6th month evaluation (GCA 34.25% vs GEA 85.25%; GCB 36% vs GEB 94.8%). The 12 month evaluation also revealed an increased RD in GEs with respect to GCs (GCA 31% vs GEA 69.2%; GCB 34% vs GEB 62.35%). These results corroborate our previous observations and show a better response in RD after the first 6 months of therapy. Mild hyperactivity was observed in about 10% of the patients during the 4 weeks of treatment. No antibody formation against FGF could be demonstrated by an ELISA test.
Fibroblast Growth Factor (FGF) Improves Perceptual Abilities in Children with Learning Problems in Scholar Age.
9th World Congress of the International Association for the Scientific Study of Mental Deficiency.
5 – 9 August 1992; Queensland, Australia.
P. ROSIQUE, C. SANCHEZ, E. PEREZ, A. ORTIZ, S. CRUZ, J.M. CANTU, L.C. AGUILAR.
Invest. Neuroplast. Des. Cel. and Div. Genet., UIBO, IMSS, Guadalajara, México.
Our group previously reported that FGF improves the developmental quotient in children with mental retardation due to brain damage. The present report concerns the evolution of scholars (aged 8 to 12 years) with learning disabilities due to perceptual deficits with antecedent of brain injury detected by evoked potentials and computerized frequency statistical analysis. Two groups were formed: controls (n=10) and treated (n=20) in which each patient received FGF (0.7 ug/kg, IM) every 2 weeks during 6 months. Both groups had the same pedagogic training. The analysis was performed using the Bender test to quantify visual-motor maturation age; arbitrary writing separation were also quantified. The results showed that children that received FGF had a significant (p<0.01) increment in visual-motor maturation age of 15 months during the six months therapeutic period.
Fibroblast Growth Factor (FGF) Improves Children with Language Disabilities.
9th World Congress of the International Association for the Scientific Study of Mental Deficiency.
5 – 9 August 1992; Queensland, Australia.
P. ROSIQUE*, E. ROCA, C. SANCHEZ, A. PEREZ, P. ROBLES, A TORIS, S. CRUZ, J.M. CANTU, L.C. AGUILAR.
Inst. Invest. Neuroplast. Des. Cel. Guadalajara, México .Previous studies of our group have shown that the IM administration of FGF improves children with mental retardation. We report here the changes in children with brain damage and language disabilities treated with FGF. Two groups, controls (n=10) and treated (n=48), were subdivided in two subgroups: comprehension and expression deficits. The treatment consisted in the IM administration of FGF (0.7 ug/kg) every 2 weeks during 6 months. Distances in the semantic network as well as phonologic were quantified in all patients. The results showed that FGF treated children from the comprehension subgroup had a reduction in the semantic distances of 20%, whereas their control group increased those distances in 49%. The expression FGF treated subgroup showed a decrease of 60% in phonologic distances, whereas in children from the control group they decreased in only 38%. These results show that FGF helps in reducing language disabilities caused by brain damage.
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